---
title: "21-TwoOne-"
description: "Takuya Kirishima is a brilliant young surgeon who can save anyone with a disease. He spends his days working with his childhood friend Seri Sasaki, who is a nur"
image: "https://t.vndb.org/cv/24/95624.jpg"
---

# 21-TwoOne-

![21-TwoOne-](https://t.vndb.org/cv/24/95624.jpg)

**Developer:** BasiL

**Release date:** May 25, 2001

**Platform:** Windows, DRC

**Language:** Japanese

**Rating:** 7.2/10 (22 votes)

## Description
Takuya Kirishima is a brilliant young surgeon who can save anyone with a disease. He spends his days working with his childhood friend Seri Sasaki, who is a nurse in the same hospital. One day, a murder is commited in the hospital and people starts suffering a strange disease not seen before. Takuya starts looking for the answer of these strange happenings so he can protect Seri.

[Translated from [Japanese Wikipedia](http://ja.wikipedia.org/wiki/21-Two_One-)]

## Characters
### Kirishima Takuya (霧島 拓哉)
- **Gender:** Male
- **Engages in:** Smoking, Investigation
- **Role:** Medical Doctor
- **Personality:** Altruistic, Kind, Protective
- **Subject of:** Avoidable Death (obsolete), Disappointment, Attempted Homicide, Asphyxia

### Futami Mao (二見　真魚)
A taciturn and unsociable girl, however, she is also a gentle girl that worries about her younger sister more than anyone else. She wants to become a doctor for the sake of curing her little sister. She holds light feelings of love for the protagonist who puts in maximum efforts without sparing anything to save patients. She wants to become a doctor like him.

[Based on the [url=http://www.oaks-soft.co.jp/princess-soft/21twoone/21chara.html]official site[/url]]

- **Gender:** Female
- **Hair:** Brown, Twin Tails, Long
- **Eyes:** Brown, Tsurime
- **Personality:** Hard Worker, Kind, Protective, Antisocial, Loyal, Docile
- **Engages in:** Cooking
- **Subject of:** Assault, Wounding, Attempted Homicide
- **Role:** Full Sister, Girlfriend, Waitstaff, High School Student, Medical Student
- **Clothes:** Maid's Dress, Maid's Headdress
- **Voiced by:** Nagasawa Miki

### Futami Mio (二見　美魚)
A girl who was admitted to the hospital that the protagonist previously worked at. Her illness was unknown, an incurable disease with no treatment. She was discharged and able to live normally as long as she didn't have any fits. She feels affection towards the protagonist, who made eager efforts to cure her, but it is the feeling of a younger sister who depends too much on her older brother, not the feeling of love.

[Based on the [url=http://www.oaks-soft.co.jp/princess-soft/21twoone/21chara.html]official site[/url]]

- **Gender:** Female
- **Hair:** Blue, Long
- **Eyes:** Brown, Tareme
- **Subject of:** Terminal Illness, Hospitalization, Curse, Weakness, Fainting, Bedridden, Mental Breakdown
- **Role:** Full Sister, High School Student
- **Personality:** Honest, Cheerful
- **Engages in:** Reading
- **Voiced by:** Hinata Yura

### Ichinose Konoha (一ノ瀬　木葉)
A girl who is honest with her own feelings - during fun times she will laugh with all her might, and during sorrowful times she will cry in a loud voice. She is mischievous and often gets caught by the nurses.

[Based on the [url=http://www.oaks-soft.co.jp/princess-soft/21twoone/21chara.html]official site[/url]]

- **Gender:** Female
- **Hair:** Pink, Wavy, Short
- **Eyes:** Green, Tareme
- **Subject of:** Split Personality, Hospitalization, Psychological Trauma, Curse, Guilt
- **Role:** Twin Sister, Immortal
- **Engages in:** Cannibalism, Self-sacrifice, Cat Cosplay
- **Personality:** Mature, Mischievous, Cheerful
- **Voiced by:** Minami Omi

### Kikyou Momiji (汽京　紅葉)
The hospital's cheerful, carefree, positive thinker. But her manners are good, and the patients deeply rely on her. Her mother was a talented doctor, and she herself matches her mother's skills. Together with the protagonist, there are big expectations for the future.

[Based on the [url=http://www.oaks-soft.co.jp/princess-soft/21twoone/21chara.html]official site[/url]]

- **Gender:** Female
- **Hair:** Blue, Short
- **Eyes:** Green
- **Personality:** Secretive, Pretending, Carefree, Friendly, Cold-hearted, Smart, Optimist, Cheerful
- **Role:** Twin Sister, Medical Doctor, Superhuman
- **Engages in:** Teasing, Cannibalism, Revenge, Manipulation
- **Subject of:** Wounding, Psychological Trauma, Guilt
- **Clothes:** Lab Coat, Torn Pantyhose (damaged)
- **Body:** Mole
- **Voiced by:** Mitsuishi Kotono

### Mihara Kasumi (三原　香澄)
Konoha's friend that often visits her in the hospital. She is a very healthy girl that can't calm down if she doesn't move her body. Whatever she does, she does it noisily. She is older that Konoha, but she certainly doesn't seem like it. She loves and respects her twin brother in a way that is not just sibling affection. It has already reached the level of love between a man and a woman.
 
[Based on the [url=http://www.oaks-soft.co.jp/princess-soft/21twoone/21chara.html]official site[/url]]

- **Gender:** Female
- **Hair:** Blond, Twin Tails, Long, Wavy
- **Engages in:** Cross-dressing, Cooking, Murder, Assault
- **Clothes:** Hair Ribbon, Ribbon Hair Tie
- **Personality:** Yandere, Friendly, Energetic, Brother Complex, Jealous, Cheerful
- **Subject of:** Insanity, Split Personality, Mental Affliction, Mental Breakdown, Manipulation, Delusion, Arrest
- **Role:** Twin Sister, Friend, High School Student
- **Voiced by:** Iizuka Mayumi

### Sakaki Seri (榊　芹)
The protagonist's childhood friend. She became a nurse to help him. She is the woman closest to the protagonist and the one that understands his pain the most. She is always cheerful and positive, but she can be a little violent towards the protagonist. But that is all intended to cheer him up, and she worries about him more than anyone else. Her feelings are obviously romantic.

[Based on the [url=http://www.oaks-soft.co.jp/princess-soft/21twoone/21chara.html]official site[/url]]

- **Gender:** Female
- **Hair:** Violet, Shoulder-length, Intake, Spiky Bangs, Hair Beads
- **Body:** Slim, Pale
- **Personality:** Hard Worker, Secretive, Boku, Carefree, Friendly, Kind, Loyal
- **Eyes:** Blue, Tareme
- **Role:** Childhood Friend, Nurse, Waitstaff, Popular
- **Clothes:** Maid's Dress, Nurse Uniform, Name Tag, Nurse's Cap
- **Engages in:** Bad Cooking
- **Voiced by:** Kawasumi Ayako

### Tachibana Yuina (橘　唯奈)
In the same way that the protagonist lost his mother and decided to become a doctor, she lost her brother and decided on the same goal. However, she was not able to realize that dream... Now, she is seeking it. A person to whom she can entrust her dream. And the power to grant her own dream again.

[Based on the [url=http://www.oaks-soft.co.jp/princess-soft/21twoone/21chara.html]official site[/url]]

- **Gender:** Female
- **Hair:** Brown, Short
- **Eyes:** Brown
- **Personality:** Hard Worker, Pretending, Selfish, Mature, Manipulative
- **Subject of:** Assault, Coma, Hospitalization, Grief, Attempted Homicide, Surgery
- **Role:** Nurse, Coworker, Not a Virgin
- **Clothes:** Nurse Uniform, Nurse's Cap
- **Voiced by:** Yukino Satsuki

### Sagawa Midori (狭川　翠)
A waitress who works part time at the tea shop and stand in the hospital. She wears a considerably special uniform that is popular among some enthusiasts. She always does things at her pace, but she is brimming with curiosity. If she becomes a little interested in something she will immediately stick her nose into it. Although she is unexpectedly a level-headed person, she has some careless points.

[Based on the [url=http://www.oaks-soft.co.jp/princess-soft/21twoone/21chara.html]official site[/url]]

- **Gender:** Female
- **Hair:** Black, Long, Straight
- **Clothes:** Kemonomimi Headband, Maid's Dress, Ribbon Hair Accessory, Maid's Headdress
- **Role:** Waitstaff
- **Personality:** Kind, Cheerful
- **Voiced by:** Toyoshima Machiko

### Masato (真聡)
A boy who appears in a lot of [url=/p13]Navel[/url] and [url=/p500]Basil[/url] games, and mischievously lifts the skirts of the heroines.

[adapted from [url=http://danbooru.donmai.us/wiki/show?title=masato_%28navel%29]Danbooru Wiki[/url]]

- **Gender:** Male
- **Aliases:** まさと, Masato
- **Hair:** Blue, Short, Straight, Spiky Bangs
- **Body:** Slim, Pale, Kid
- **Personality:** Boku, Pervert, Mischievous, Opposite Gender Voiced
- **Engages in:** Teasing, Not Sexually Involved
- **Eyes:** Itome

## Shops
- [Official Website](https://web.archive.org/web/20090921233814/http://www.basil-soft.jp/mogitate/index.htm)
- [DLsite](https://www.dlsite.com/pro/work/=/product_id/VJ005438.html)
- [Getchu](http://www.getchu.com/soft.phtml?id=639425)

## Releases
### Japanese
- **2001-05-25**: 21-Two One- First Press Limited Edition - [Official website](http://www.oaks-soft.co.jp/princess-soft/21twoone/index.html), [ErogameScape](https://erogamescape.dyndns.org/~ap2/ero/toukei_kaiseki/game.php?game=1432), [Getchu](http://www.getchu.com/soft.phtml?id=5380)
- **2001-06-08**: 21-Two One- Regular Edition - [Official website](http://www.oaks-soft.co.jp/princess-soft/21twoone/index.html), [Getchu](http://www.getchu.com/soft.phtml?id=7360)
- **2001-12-27**: 21-Two One- Regular Edition - [Official website](http://www.oaks-soft.co.jp/princess-soft/21twoone/index.html), [ErogameScape](https://erogamescape.dyndns.org/~ap2/ero/toukei_kaiseki/game.php?game=5621)
- **2001-12-27**: 21-Two One- First Press Limited Edition - [Official website](http://www.oaks-soft.co.jp/princess-soft/21twoone/index.html), [ErogameScape](https://erogamescape.dyndns.org/~ap2/ero/toukei_kaiseki/game.php?game=5621), [PlayAsia](https://www.play-asia.com/13/701wrd), [PlayAsia](https://www.play-asia.com/13/70499p)
- **2002-10-31**: 21-Two One- DreKore - [Official website](http://www.oaks-soft.co.jp/princess-soft/21twoone/index.html)
- **2009-07-31**: Mogitate BasiL! -commencement- - [Official website](https://web.archive.org/web/20090921233814/http://www.basil-soft.jp/mogitate/index.htm), [ErogameScape](https://erogamescape.dyndns.org/~ap2/ero/toukei_kaiseki/game.php?game=12510), [Getchu](http://www.getchu.com/soft.phtml?id=639425)
- **2010-07-06**: 21-Two One- Download Edition - [DLsite](https://www.dlsite.com/pro/work/=/product_id/VJ004871.html), [Gyutto](https://gyutto.com/i/item39606), [Digiket](https://www.digiket.com/work/show/_data/ID=ITM0043520/), [DL.Getchu](http://dl.getchu.com/i/item1002495)
- **2011-01-07**: Mogitate BasiL! -commencement- Download Edition - [Official website](https://web.archive.org/web/20090921233814/http://www.basil-soft.jp/mogitate/index.htm), [DLsite](https://www.dlsite.com/pro/work/=/product_id/VJ005438.html), [Gyutto](https://gyutto.com/i/item17841), [Digiket](https://www.digiket.com/work/show/_data/ID=ITM0049829/), [DL.Getchu](http://dl.getchu.com/i/item1002963), [DMM](https://dlsoft.dmm.co.jp/detail/ggs_0511/)

## Tags
Fantasy, Fear of Death, ADV, Male Protagonist, Murder Mystery, Bloody Scenes, Life and Death Drama, Sickly Heroine, Nameable Protagonist, Dying Heroine, Illness, Immortal Heroine, Madness, Heroine with Multiple Personalities, Revenge, Heroine with Zettai Ryouiki, Heroine with Sexual Experience, Heroine with Psychological Problems, Curse, Multiple Route Mystery, Medical Doctor Protagonist, Nakige, Depression (obsolete), Nurse Heroine, Medical Doctor Heroine, Bad Ending(s), Defloration, Smoker Protagonist, Cannibalism, Autumn, More Than Seven Endings, Sacrifice, Brocon Heroine, Relationship Chart, Homicide, Avoidable Death of Protagonist (obsolete), High School Student Heroine

## More Games from BasiL
- [BLESS ~CLOSE YOUR EYES,OPEN YOUR MIND.~](https://pinovel.net/v3759)
- [21-TwoOne-](https://pinovel.net/v1823)
- [210 -Two One Zero-](https://pinovel.net/v10481)
- [Sore wa Maichiru Sakura no You ni](https://pinovel.net/v1115)

---
*View the full details at [pinovel.net/v1823](https://pinovel.net/v1823).*

```json
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```